聲音治療為目前臨床中常使用的慢性耳鳴療法之一,且多以白噪音為主。目的為幫助患者放鬆,以及調節因耳鳴引起的異常神經元活動。然而白噪音的體驗感受不佳,導致在臨床中並不盛行。有鑑於此,本研究透過重採樣實現變調搭配波型相似疊加演算建立移頻聲音療法 (PMST),其將耳鳴頻率鑲嵌在特定音樂當中達到遮蔽效果。為驗證本方法可行性,本研究設計四種腦波實驗,分別為比較白噪音與PMST 刺激對於健康人大腦放鬆評估;健康人與耳鳴病患間的腦波特徵差異;短期PMST 治療前後腦波特徵變化;紀錄 30 天 PMST 治療前後的腦波與主觀問卷分析。實驗一結果顯示相較於白噪音,PMST 更能夠反映出大腦放鬆特徵α 波上升(p=0.0518)以及β波顯著下降 (p<0.05),反之白噪音則相反;實驗二發現耳鳴患者相較於健康人的δ頻帶活動異常,α功率減少且全腦網絡明顯增加;實驗三在短期PMST 治療使耳鳴患者的δ、α變化趨近於健康人,θ反映出較好的聽覺記憶;實驗四在長期治療後,發現全腦網絡顯著下降 (p<0.05),特別是在雙側顳葉;THI 分數顯示患者耳鳴由重度下降至中度;VAS 量表平均下降 4.7;李克特 5 級 PMST 治療體驗量表滿意度超過 4分,PMST提供了慢性耳鳴病患長期聲音治療的新穎選擇。基於上述成果,本研究使用 OpenBCI Cyton 感測晶片開發居家型智慧耳鳴治療耳機,並設計聽覺不匹配負向波(MMN)實驗,驗證此穿戴式腦電圖感測晶片可行性,結果顯示在刺激後的 0.15 s 中發現 MMN,符合聽覺刺激機制,該輕量型生醫感測晶片展示未來產品化方面的潛力。

 

 

Sound therapy is one of the commonly used treatments for chronic tinnitus in clinical practice, mostly utilizing white noise (WN). The aim is to help patients relax and regulate the abnormal neuronal activities caused by tinnitus. However, the experience of WN is often unpleasant, leading to its limited prevalence in clinical settings. In view of this, our study developed a Pitch Modulation Sound Therapy (PMST) by implementing resampling techniques to achieve pitch modulation combined with Waveform Similarity Overlap-Add. This method embeds tinnitus frequency into specific music to achieve a masking effect. To verify the feasibility of this treatment, we designed four EEG experiments: relaxed evaluation of WN and PMST comparison of EEG between healthy individuals and tinnitus patients, EEG characteristics before and after short-term PMST treatment, recording and analyzing EEG and subjective questionnaire responses before and after 30 days of PMST treatment. Results of the first experiment indicated that compared to WN, PMST showed more effectively reflected brain relaxation with a significant increase in α (p=0.0518) and a significant decrease in β (p<0.05), while the opposite was observed for WN. The second experiment found abnormal δ activity, reduced α power, and significantly increased brain network activity in tinnitus patients compared to healthy individuals. The third experiment shows that short-term PMST treatment causes δ and α changes in tinnitus patients to approach those of healthy individuals. θ reflects the normalization of auditory memory retrieval. The fourth experiment revealed a significant reduction in brain network activity (p<0.05) after long-term treatment, particularly in the temporal lobes; THI scores indicate a

reduction from severe to moderate; the VAS scale shows an average decrease of 4.7; and the Likert scale for PMST treatment satisfaction exceeded 4 points. PMST provides a novellong-term sound therapy option for chronic tinnitus patients. Based on these results, we use the OpenBCI Cyton biosensing chip to develop home-based intelligent therapeutic headphones. To verify the feasibility of this wearable EEG biosensing chip. We design an auditory mismatch negativity (MMN) experiment. The result shows the presence of MMN at 0.15 seconds, consistent with auditory stimulus mechanisms. Demonstrate the potential for future product commercialization of this lightweight biomedical sensing chip.

modulation sound therapy, EEG, Home-based intelligent聲音治療為目前臨床中常使用的慢性耳鳴療法之一,且多以白噪音為主。目的

為幫助患者放鬆,以及調節因耳鳴引起的異常神經元活動。然而白噪音的體驗感受

不佳,導致在臨床中並不盛行。有鑑於此,本研究透過重採樣實現變調搭配波型相

似疊加演算建立移頻聲音療法 (PMST),其將耳鳴頻率鑲嵌在特定音樂當中達到遮蔽

效果。為驗證本方法可行性,本研究設計四種腦波實驗,分別為比較白噪音與

PMST 刺激對於健康人大腦放鬆評估;健康人與耳鳴病患間的腦波特徵差異;短期

PMST 治療前後腦波特徵變化;紀錄 30 天 PMST 治療前後的腦波與主觀問卷分析。

實驗一結果顯示相較於白噪音,PMST 更能夠反映出大腦放鬆特徵α 波上升

(p=0.0518)以及β波顯著下降 (p<0.05),反之白噪音則相反;實驗二發現耳鳴患者相

較於健康人的δ頻帶活動異常,α功率減少且全腦網絡明顯增加;實驗三在短期

PMST 治療使耳鳴患者的δ、α變化趨近於健康人,θ反映出較好的聽覺記憶;實驗四

在長期治療後,發現全腦網絡顯著下降 (p<0.05),特別是在雙側顳葉;THI 分數顯示

患者耳鳴由重度下降至中度;VAS 量表平均下降 4.7;李克特 5 級 PMST 治療體驗量

表滿意度超過 4分,PMST提供了慢性耳鳴病患長期聲音治療的新穎選擇。基於上述

成果,本研究使用 OpenBCI Cyton 感測晶片開發居家型智慧耳鳴治療耳機,並設計

聽覺不匹配負向波(MMN)實驗,驗證此穿戴式腦電圖感測晶片可行性,結果顯示在

刺激後的 0.15 s 中發現 MMN,符合聽覺刺激機制,該輕量型生醫感測晶片展示未來

產品化方面的潛力。

 

關鍵字:慢性耳鳴、聲音治療、波型相似疊加演算法、腦電圖、移頻聲音療法、居

家型智慧耳鳴治療耳機、不匹配負向波

 

II

Abstract

 

Sound therapy is one of the commonly used treatments for chronic tinnitus in clinical

practice, mostly utilizing white noise (WN). The aim is to help patients relax and regulate

the abnormal neuronal activities caused by tinnitus. However, the experience of WN is often

unpleasant, leading to its limited prevalence in clinical settings. In view of this, our study

developed a Pitch Modulation Sound Therapy (PMST) by implementing resampling

techniques to achieve pitch modulation combined with Waveform Similarity Overlap-Add.

This method embeds tinnitus frequency into specific music to achieve a masking effect. To

verify the feasibility of this treatment, we designed four EEG experiments: relaxed

evaluation of WN and PMST comparison of EEG between healthy individuals and tinnitus

patients, EEG characteristics before and after short-term PMST treatment, recording and

analyzing EEG and subjective questionnaire responses before and after 30 days of PMST

treatment. Results of the first experiment indicated that compared to WN, PMST showed

more effectively reflected brain relaxation with a significant increase in α (p=0.0518) and a

significant decrease in β (p<0.05), while the opposite was observed for WN. The second

experiment found abnormal δ activity, reduced α power, and significantly increased brain

network activity in tinnitus patients compared to healthy individuals. The third experiment

shows that short-term PMST treatment causes δ and α changes in tinnitus patients to

approach those of healthy individuals. θ reflects the normalization of auditory memory

retrieval. The fourth experiment revealed a significant reduction in brain network activity

(p<0.05) after long-term treatment, particularly in the temporal lobes; THI scores indicate a

reduction from severe to moderate; the VAS scale shows an average decrease of 4.7; and the

Likert scale for PMST treatment satisfaction exceeded 4 points. PMST provides a novel

long-term sound therapy option for chronic tinnitus patients. Based on these results, we use

 

III

 

the OpenBCI Cyton biosensing chip to develop home-based intelligent therapeutic

headphones. To verify the feasibility of this wearable EEG biosensing chip. We design an

auditory mismatch negativity (MMN) experiment. The result shows the presence of MMN

at 0.15 seconds, consistent with auditory stimulus mechanisms. Demonstrate the potential

for future product commercialization of this lightweight biomedical sensing chip.

 

Keywords: Chronic tinnitus, Sound therapy, Waveform Similarity Overlap-Add, Pitch

modulation sound therapy, EEG, Home-based intelligent